abstract：:The otoprotective peptide AM-111, a cell-permeable inhibitor of JNK mediated apoptosis, was tested for its efficacy as a rescue agent following impulse noise trauma. Single dose administrations of AM-111 at 1h or 4h post-impulse noise exposure (155 dB peak SPL) via systemic or local routes were evaluated with a total ...

journal_title：Hearing research

authors： Coleman JK,Littlesunday C,Jackson R,Meyer T

更新日期：2007-04-01 00:00:00

abstract：:Previous claims that auditory stream segregation occurs in cochlear implant listeners are based on limited evidence. In experiment 1, eight listeners heard tones presented in a 30-s repeating ABA-sequence, with frequencies matching the centre frequencies of the implant's 22 electrodes. Tone A always stimulated electro...

journal_title：Hearing research

authors： Cooper HR,Roberts B

更新日期：2007-03-01 00:00:00

abstract：:The analysis of the auditory scene begins from the moment we hear sounds, making it possible for the infant to distinguish the mother's voice from other sounds in the environment. The purpose of the study was to determine, in two experiments, whether the frequency separation threshold, at which the perception of a mix...

journal_title：Hearing research

authors： Sussman E,Wong R,Horváth J,Winkler I,Wang W

更新日期：2007-03-01 00:00:00

abstract：:Using morphological criteria, death pathways in outer hair cells (OHCs) were determined in chinchilla organs of Corti that had been exposed to a high- or moderate-level octave band of noise (OBN) centered at either 0.5 or 4-kHz. The specimens were part of our large collection of plastic-embedded flat preparations of c...

journal_title：Hearing research

authors： Bohne BA,Harding GW,Lee SC

更新日期：2007-01-01 00:00:00

abstract：:Chronic tinnitus is often accompanied by a hearing impairment, but it is still unknown whether hearing loss can actually cause tinnitus. The association between the pitch of the tinnitus sensation and the audiogram edge in patients with high-frequency hearing loss suggests a functional relation, but a large fraction o...

journal_title：Hearing research

authors： König O,Schaette R,Kempter R,Gross M

更新日期：2006-11-01 00:00:00

abstract：:Otoacoustic emissions (OAEs) are weak sounds that originate from the inner ear which are traditionally classified/named based on their evoking stimulus. Recently, it has been argued that such a classification, at least for mammals, misrepresents the underlying mechanisms of emission-generation. As an alternative class...

journal_title：Hearing research

authors： Meenderink SW,Narins PM

更新日期：2006-10-01 00:00:00

abstract：:The central nucleus of the inferior colliculus (CNIC) contains different types of neurons and is a source of ascending projection to the medial geniculate body (MGB), commissural projection to the contralateral IC, direct descending projection to the cochlea nucleus (CN) and indirect projection to the CN via the super...

journal_title：Hearing research

authors： Okoyama S,Ohbayashi M,Ito M,Harada S

更新日期：2006-08-01 00:00:00

abstract：:The standard procedure to study temporal encoding of sound waveforms in the auditory system has been Fourier analysis of responses to periodic stimuli. We introduce a new metric--correlation index (CI)--which is based on a simple counting of spike coincidences. It can be used for responses to aperiodic stimuli and doe...

journal_title：Hearing research

authors： Joris PX,Louage DH,Cardoen L,van der Heijden M

更新日期：2006-06-01 00:00:00

abstract：:An anatomically based model of cochlear neuron electrophysiology has been developed and used to interpret the physiological responses of the auditory neuron to electrical summation and refractory pulse-pair stimuli. For summation pulses, the summation time constant, tau(sum), indicates the ability of the membrane to h...

journal_title：Hearing research

authors： Cartee LA

更新日期：2006-05-01 00:00:00

abstract：:The latency of the N100m component of the auditory evoked field (AEF) is sensitive to the period and spectrum of a sound. However, little attention was paid so far to the wave shape at stimulus onset, which might have biased previous results. This problem was fixed in the present study by aligning the first major peak...

journal_title：Hearing research

authors： Seither-Preisler A,Patterson R,Krumbholz K,Seither S,Lütkenhöner B

更新日期：2006-03-01 00:00:00

abstract：:In ears in which cochlear efferent pathways were cut and with testing done under anaesthetic conditions that preclude middle ear muscle activity (so as to examine the "intrinsic" effects of loud sound on the cochlea without any confounding effect of efferent pathways to the auditory periphery), atraumatic background w...

journal_title：Hearing research

authors： Rajan R

更新日期：2006-03-01 00:00:00

abstract：:With the aim of characterizing the loss of high frequency hearing sensitivity in children, hearing thresholds and otoacoustic emissions were measured in a group of 126 normal hearing children and adolescents aged from 6 to 25 years. The subjects were divided into four 5-year age groups. Hearing thresholds over a range...

journal_title：Hearing research

authors： Groh D,Pelanova J,Jilek M,Popelar J,Kabelka Z,Syka J

更新日期：2006-02-01 00:00:00

abstract：:Decrement detection is a commonly used psychophysical technique in which a subject is required to detect partially filled gaps in an ongoing sound. The paradigm provides information regarding both temporal resolution and intensity discrimination. The purpose of this project was to determine if an evoked-potential para...

journal_title：Hearing research

authors： Boettcher FA,Emery M

更新日期：2006-02-01 00:00:00

abstract：:There is conflict in the literature over whether individual frequency components of a transient-evoked otoacoustic emission (TEOAE) are generated within relatively independent "channels" along the basilar membrane (BM), or whether each component may be generated by widespread areas of the BM. Two previous studies on T...

journal_title：Hearing research

authors： Killan EC,Kapadia S

更新日期：2006-02-01 00:00:00

abstract：:The responses to two identical, consecutive pure tone stimuli with varying inter-stimulus intervals (delta ts) were measured for 89 neurons in the cochlear nucleus of the anaesthetised guinea pig. We observed two main effects; either a decrease (suppression) or an increase (facilitation) in response to the second tone...

journal_title：Hearing research

authors： Bleeck S,Sayles M,Ingham NJ,Winter IM

更新日期：2006-02-01 00:00:00

abstract：:In common inbred mouse strains, hearing loss is a highly prevalent quantitative trait, which is mainly controlled by the Cdh23(753A) variant and alleles at numerous other strain-specific loci. Here, we investigated the genetic basis of hearing loss in non-inbred strains. Mice of Swiss Webster, CF-1, NIH Swiss, ICR, an...

journal_title：Hearing research

authors： Drayton M,Noben-Trauth K

更新日期：2006-02-01 00:00:00

abstract：:We have compared the effects of microiontophoretic application of the GABA(A)-receptor antagonists bicuculline (BIC) and gabazine (SR95531) on responses to pure tones and to sinusoidally amplitude-modulated (AM) tones in cells recorded extracellularly from primary auditory cortex (AI) of Mongolian gerbils. Besides sim...

journal_title：Hearing research

authors： Kurt S,Crook JM,Ohl FW,Scheich H,Schulze H

更新日期：2006-02-01 00:00:00

abstract：:We have injected by iontophoresis 4-amino-pyridine, a K+ channel blocker and BAPTA, (a Ca++ chelator), into scala media of the first three turns of the guinea pig cochlea. We measured the reduction in outer hair cell (OHC) receptor current, as indicated by cochlear microphonic measured in scala media evoked by a 207 H...

journal_title：Hearing research

authors： Sellick PM,Robertson D,Patuzzi R

更新日期：2006-01-01 00:00:00

abstract：:Two-tone stimuli have traditionally been used to reveal regions of inhibition in auditory spectral receptive fields, particularly for neurons with low spontaneous rates. These techniques reveal how different frequencies excite or suppress the response to an excitatory frequency of a cell, but have often been assessed ...

journal_title：Hearing research

authors： Brimijoin WO,O'Neill WE

更新日期：2005-12-01 00:00:00

abstract：:Dominant white spotting W/W(v) and W(v)/W(v) mice are well-known mutants that lack strial intermediate cells in their cochlea and manifest hereditary sensorineural hearing loss. We recently reported marked thickening of and IgG deposition on the basement membrane of strial capillaries in W/W(v) mutant mice, similar to...

journal_title：Hearing research

authors： Fujimura T,Suzuki H,Shimizu T,Tokui N,Kitamura T,Udaka T,Doi Y

更新日期：2005-11-01 00:00:00

abstract：:The field L complex is thought to be the highest auditory centre and the input in the song vocal nuclei. Different anatomical and functional subdivisions have been described in field L. Auditory neurons of field L are well activated by natural sounds and especially by species-specific sounds. A complex sound coding ap...

journal_title：Hearing research

authors： Cousillas H,Leppelsack HJ,Leppelsack E,Richard JP,Mathelier M,Hausberger M

更新日期：2005-09-01 00:00:00

abstract：:In this paper, research on the temporal and spatial distribution of cholinergic-related molecules in the lower auditory brainstem, with an emphasis on nicotinic acetylcholine receptors (nAChRs), is reviewed. The possible functions of acetylcholine (ACh) in driving selective auditory neurons before the onset of hearing...

journal_title：Hearing research

authors： Morley BJ

更新日期：2005-08-01 00:00:00

abstract：:A growing body of evidence implies that the dorsal cochlear nucleus (DCN) plays an important role in tinnitus. To test the hypothesis that the rostral output of the DCN is necessary for the experience of chronic tinnitus, the dorsal DCN and the dorsal acoustic stria of rats with psychophysical evidence of tinnitus was...

journal_title：Hearing research

authors： Brozoski TJ,Bauer CA

更新日期：2005-08-01 00:00:00

abstract：:The distribution of neurotensin-containing cell bodies and fibers has been observed in the central and peripheral nervous system, including sensory ganglia, but no description has been found in the peripheral auditory system. Here, we investigated the presence of neurotensin immunoreactivity in the cochlea of the adul...

journal_title：Hearing research

authors： Gomide VC,de Francisco AC,Chadi G

更新日期：2005-07-01 00:00:00

abstract：:Extracellular adenosine has been suggested as a modulator of cochlear function. To date the release of adenosine into the extracellular spaces of the cochlea has not been demonstrated. Therefore, experiments were designed to examine whether adenosine release into perilymph could be detected in response to depolarizati...

journal_title：Hearing research

authors： Bobbin RP,Bledsoe SC Jr

更新日期：2005-07-01 00:00:00

abstract：:Human behavioral thresholds for trains of biphasic pulses applied to a single channel of Nucleus CI24 and LAURA cochlear implants were measured as a function of inter-phase gap (IPG). Experiment 1 used bipolar stimulation, a 100-pps pulse rate, and a 400-ms stimulus duration. In one condition, the two phases of each p...

journal_title：Hearing research

authors： Carlyon RP,van Wieringen A,Deeks JM,Long CJ,Lyzenga J,Wouters J

更新日期：2005-07-01 00:00:00

abstract：:Degeneration of spiral ganglion neurons (SGNs) in the cochlea following sensorineural hearing loss is preventable by the infusion of neurotrophins into the scala tympani. This study investigates the trophic effects and distribution of a single bolus infusion of neurotrophin-3 (NT3) into the scala tympani of the cochle...

journal_title：Hearing research

authors： Richardson RT,O'Leary S,Wise A,Hardman J,Clark G

更新日期：2005-06-01 00:00:00

abstract：:The peripheral auditory sense organ, the cochlea, receives innervation from lateral and medial olivocochlear neurons in the brainstem. These neurons are able to modulate cochlear neural output. Anatomical studies have shown that one of the neurotransmitters which is present in varicosities surrounding the olivocochlea...

journal_title：Hearing research

authors： Mulders WH,Robertson D

更新日期：2005-06-01 00:00:00

abstract：:In recent years, new designs of cochlear implant electrodes have been introduced in an attempt to improve efficiency and performance by locating stimulation sites closer to spiral ganglion neurons and deeper into the scala tympani. The goal of this study was to document insertion depth, intracochlear position and inse...

journal_title：Hearing research

authors： Wardrop P,Whinney D,Rebscher SJ,Roland JT Jr,Luxford W,Leake PA

更新日期：2005-05-01 00:00:00

abstract：:Stress can be a significant factor influencing ear pathologies and is often reported to trigger the symptoms of Meniere's disease. Both physiological and psychological stress provokes the release of prolactin from the pituitary thus allowing the classification of prolactin as a major stress hormone. We investigated th...

journal_title：Hearing research

authors： Falkenius-Schmidt K,Rydmarker S,Horner KC

更新日期：2005-05-01 00:00:00

abstract：:Genetically manipulated mice have gained a prominent role in in vivo research on development and function of the auditory system. A prerequisite for the interpretation of normal and abnormal structural and functional features of the inner ear is the exact knowledge of the cochlear place-frequency map. Using a stereota...

journal_title：Hearing research

authors： Müller M,von Hünerbein K,Hoidis S,Smolders JW

更新日期：2005-04-01 00:00:00

abstract：:The role of the endolymphatic sac (ES) in endolymph volume homeostasis is speculative. The present study investigates changes of the ES's epithelia and luminal filling after induction of an acute endolymphatic hydrops. After microinjection of 1.1 mul artificial endolymph into scala media of the cochlea, guinea pigs we...

journal_title：Hearing research

authors： Valk WL,Wit HP,Segenhout JM,Dijk F,van der Want JJ,Albers FW

更新日期：2005-04-01 00:00:00

abstract：:Cochlear compression in normal-hearing listeners was estimated at octave frequencies from 250 to 4000 Hz using a forward-masking paradigm. Temporal masking curves (TMCs) for a 10-dB SL signal were obtained with two maskers -- one equal in frequency to the signal and another an octave below the signal. The ratio of the...

journal_title：Hearing research

authors： Williams EJ,Bacon SP

更新日期：2005-03-01 00:00:00

abstract：:Psychophysical measures of the electrically stimulated human auditory system were obtained for different types of symmetric and asymmetric charge-balanced waveforms. Absolute detection thresholds of biphasic, pseudomonophasic, and 'alternating monophasic' current waveforms delivered by a bipolar intra-cochlear electro...

journal_title：Hearing research

authors： van Wieringen A,Carlyon RP,Laneau J,Wouters J

更新日期：2005-02-01 00:00:00

abstract：:Bushy cells of the ventral cochlear nucleus produce a single, short latency action potential at the beginning of long depolarisations. In the present work an immunochemical survey was performed to detect the presence of K+ channel subunits which may contribute to the specific membrane properties of the bushy cells. Th...

journal_title：Hearing research

authors： Pál B,Pór A,Pocsai K,Szücs G,Rusznák Z

更新日期：2005-01-01 00:00:00

abstract：:Noise over-stimulation will induce or influence molecular pathways in the cochlea; one approach to the identification of the components of these pathways in the cochlea is to examine genes and proteins that change following different types and levels of stress. Quantitative reverse transcription polymerase chain react...

journal_title：Hearing research

authors： Caravelli A,Pianese L,Saulino C,Di Leva F,Sequino L,Cocozza S,Marciano E,Franzé A

更新日期：2004-12-01 00:00:00

abstract：:Mortality is a major complication in animal models of cisplatin-induced hearing loss due to the systemic toxicity of the drug. Here we report on a novel two-cycle treatment in rats, each cycle consisting of four days of cisplatin injections (1 mg/kg, i.p., twice daily) separated by 10 days of rest. This regimen, simil...

journal_title：Hearing research

authors： Minami SB,Sha SH,Schacht J

更新日期：2004-12-01 00:00:00

abstract：:Mutations in GJB2 account for the majority of recessive forms of prelingual hearing loss. However, in most previous studies it was not possible to distinguish between congenital (present at birth) and non-congenital prelingual hearing loss. In the present study, the frequency of GJB2 alleles in 20 newborns with bilate...

journal_title：Hearing research

authors： Shi GZ,Gong LX,Xu XH,Nie WY,Lin Q,Qi YS

更新日期：2004-11-01 00:00:00

abstract：:Six utricular hair bundles from a red-eared turtle are modeled using 3-D finite element analysis. The mechanical model includes shear deformable stereocilia, realignment of all forces during force load increments, and tip and lateral link inter-stereocilia connections. Results show that there are two distinct bundle t...

journal_title：Hearing research

authors： Silber J,Cotton J,Nam JH,Peterson EH,Grant W

更新日期：2004-11-01 00:00:00

abstract：:Uncoupling proteins (UCPs) are a proton transporter family located in the mitochondrial inner membrane. The molecular expression and activity of UCPs in brown adipose tissue and skeletal muscle are regulated by factors as diverse as chronic overeating and cold exposure, suggesting roles in energy expenditure and heat ...

journal_title：Hearing research

authors： Kitahara T,Li HS,Balaban CD

更新日期：2004-10-01 00:00:00